commit 366703483da9b8c11626a3b46ef322a0fdcc8836 Author: chassidymurama Date: Fri Apr 3 02:46:50 2026 +0800 Add Testosterone suppression of the HPT axis diff --git a/Testosterone-suppression-of-the-HPT-axis.md b/Testosterone-suppression-of-the-HPT-axis.md new file mode 100644 index 0000000..60c3f49 --- /dev/null +++ b/Testosterone-suppression-of-the-HPT-axis.md @@ -0,0 +1,7 @@ +
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In various other studies, similar findings were reported where subjects who were administered higher amounts of Vitamin D over time demonstrated vast increases in total [testosterone purchase](http://183.6.47.107:30000/edith712244122) levels, and decreases in SHBG. In all studies involving Nolvadex doses used to stimulate endogenous [buy testosterone booster](http://139.196.179.195:3000/octaviagoodell) production, only 20 – 40mg daily of Nolvadex was utilized, and it has in fact been shown that doubling the dose to 40mg or any higher will not produce any significant difference in endogenous [buy testosterone pills](https://ttym.space/luciennemacart) secretion. Studies have demonstrated that 150mg of Clomid (Clomiphene Citrate) administered daily raised endogenous [buy testosterone enanthate](https://classifieds.ocala-news.com/author/vedakroeger) levels of 10 healthy males by approximately 150%, while incidentally, 20mg of Nolvadex (Tamoxifen Citrate) daily raised endogenous [buy testosterone steroids](http://60.247.225.25:3000/eltonwelsby787/5534124.236.46.74/wiki/Testosterone-or-17beta-estradiol-exposure-reveals-sex-specific-effects-on-glucose-and-lipid-metabolism-in-human-myotubes) levels by the same amount. Secondly, Nolvadex on a mg for mg basis is far more effective than Clomid in stimulating endogenous [buy testosterone enanthate online](https://job.dialnumber.in/profile/demetriuseddin) production, as well as being a more cost-effective choice than Clomid itself. Finally, in addition to these benefits from Aromasin, it is very clear that Aromasin holds the ability to increase [buy testosterone cream online](http://43.136.169.169:3000/levieddington9) levels in males as demonstrated by studies. In one study, Aromasin displayed no such reduced effectiveness or any reduced blood plasma levels when utilized with Nolvadex. It should also be noted that it will cause an increase in testicular progesterone levels. +This was initially thought to be due to hypothyroidism causing lowered Sex Hormone Binding Globulin (SHBG) levels, though we will also note such patients have low free T too; it normalizes when hypothyroidism is treated 9. The cycle continues, going up and down around baseline, much like in the HPTA. It also reduces the production of GnRH in the hypothalamus. DHT, T & E2 tell the anterior pituitary to basically reduce the amount of LH & FSH released. Some of that T gets converted into Oestradiol (E2) and some to Dihydrotestosterone (DHT), and some is made in the testes. +Prenatal exposure to alcohol can affect the hormones regulating fetal development resulting in foetal alcohol spectrum disorder. Starvation from anorexia nervosa or bulimia causes the HPG axis to deactivate causing women's ovarian and uterine cycles to stop. Although often described as preventing pregnancy by mimicking the pregnancy state, hormonal birth control is effective because it works on the HPG axis to mimic the luteal phase of a woman's cycle. Chromosomal mutations tend to affect the androgen production rather than the HPG axis.citation needed During development, hormones help determine how neurons synapse and migrate to result in sexual dimorphisms. As males age, the testes begin to produce less [buy testosterone enanthate](https://lovematch.com.tr/@twylaburn54300), leading to a condition known as post-pubertal hypogonadism. +The first of the two remaining issues to be addressed will be the fact that HCG will trigger increases in testicular aromatase expression, and result in Estrogen increases in the body. Following this line of thought, the other two compounds (the SERM and the AI) are to be utilized as supportive compounds for HCG use in this 1 – 2 week period, and [hbcustream.com](https://hbcustream.com/@larhondafreund?page=about) after HCG is discontinued early on in PCT, only the SERM is to be used in order to carry along the hormonal recovery process. Studies have in fact demonstrated the incredible effectiveness of HCG for this purpose, and it is even suggested clinically that HCG be utilized for the purpose of treating anabolic steroid induced hypogonadism. +This axis involves the hypothalamus, pituitary gland, and gonads (testes), which work together to control the production of testosterone and other hormones critical for male health. As the body of evidence grows in support of restorative therapies for recovery of spermatogenesis in this patient population, it is important to be familiar with the various treatment options, their effects on the HPG axis, and when to use them. Therefore, SERMs function to block estrogen feedback thereby increasing GnRH and gonadotropin production and ultimately increasing ITT levels in men without evidence of primary hypogonadism.16,63,64 Clinically, tamoxifen and CC are two of the most commonly used SERMs, with the former popularized by use in breast cancer treatment protocols and the latter popularized by its initial development for triggering ovulation in women. In men, normal binding of estrogen at these receptors functions as an indirect negative feedback mechanism of endogenous testosterone production to downregulate GnRH and subsequently pituitary gonadotropin production. The use of exogenous androgens can influence the HPG axis by similar mechanisms as endogenous [buy testosterone steroids](http://106.15.235.242/courtneystampe) by exerting negative feedback in a dose- and duration-dependent fashion, resulting in reductions in ITT, blunting of FSH production, and ultimately decrease or complete cessation of spermatogenesis.29 Data specifically describing the natural history of unassisted spermatogenesis recovery after long-term TRT are lacking, but such information can be extrapolated from the male contraceptive literature.16 Multiple and international trials using various [buy testosterone powder](https://docentesdeingles.ec/employer/enclomiphene-before-and-after-real-results-timeline-and-what-to-expect/) preparations have been performed and demonstrate a median time to spermatogenesis suppression to 6 ml-1 sperm within 3.5 months. +
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